{2101700-15-4 pirtobrutinib

Airíonna

Dealramh bán go soladach buí
Fiuchphointe: 619.2 ± 55. {0 Céim
Dlús 1.44 ± 0. 1 g/cm3
Teocht stórála. 4 chéim, stóráilte faoi nítrigin
Tuaslagthacht DMSO: 50 mg/ml (104.29 mm; de dhíth ar ultrasonach)
PKA13.32 ± 0. 46

 

Iarratas:

Is btki an chéad ghlúin eile an-roghnach é Pirtobrutinib a sháraíonn frithsheasmhacht in aghaidh BTKI comhfhiúsach trí shuíomh ceangailteach ATP BTK a bhlocáil trí cheangal neamh-chomhfhiúsach, neamh-C481. Is féidir an táirge seo a úsáid le haghaidh lymphoma cille maintlín teasfhulangacha atá athiompaithe (MCL) a ndéileáiltear leo le tríú líne agus le teiripe shistéamach os cionn (lena n -áirítear cóireáil le coscairí BTK eile). Is é Pirtobrutinib an chéad agus an t -aon choscóir BTK neamh -chomhfhiúsach (inchúlaithe) a cheadaigh an FDA, agus an chéad domhan freisin.

 

Comhchiallaigh:

Pirtobrutinib

2101700-15-4

(S) -5- amino {-3- (4- ((5- fluoro -2- methoxybenzamido) phenyl) ) {-1- (1,1, {1- trifluoropropan -2- yl) -1 h-pyrazole -4- Carboxamide

1H-pyrazole -4- carboxamide, {5- Amino {-3- (4- (((5- fluoro -2- aimín methoxybenzoyl) Hyl) phenyl) -1- ((1S) -2, 2, 2- trifluoro -1- meitilitil)-

{5- amino -3- ({4- ((5- fluoro -2- methoxybenzamido) phenyl) -1- .

{5- Amino -3- [{4- [[(5- fluoro -2- methoxybenzoyl) aimín] pheny l] -1- [(2S) {-1, 1, 1- trifluOropropan -2- yl] pyrazole -4- Carboxamide

{5- Amino -3- {{4- [(5- fluoro -2- methoxybenzamido) methyl]} -1- [(2S) {-1, 1, {1- trifluoropropan -2- yl]

BTK Inhibitor 16

pirtobrutinibum

1H-pyrazole -4- carboxamide, {5- Amino {-3- [{4- [[(5- fluoro -2- methoxybenzoyl) aimín] hyl] phenyl] -1- [(1S) -2, 2, 2- trifluoro -1- Methylethyl]-

{5- Amino -3- ({4- {[(5- fluoro -2- methoxyphenyl) meitil} phen yl) -1- [(2S) {-1, 1, 1- trifluoropropan -2- yl] pyrazole -4- Carboxamide

BTK inhibitor loxo -305

Pirtobrutinib

{5- amino -3- [{4- [[(5- fluoro -2- methoxybenzoyl) aimín] feinil] {{5} } [(1S) -2, 2, {2- trifluoro -1- methylethyl] -1 h-pyrazole -4- carboxamide

 

 

 

Clibeanna Te: {2101700-15-4 pirtobrutinib, an tSín 2101700-15-4 déantúsóirí pirtobrutinib, soláthróirí