{936727-05-8 lumacaftor (vx -809)

Airíonna

Cuma bán ar sholad as-bán

Leáphointe: {200-205 oc

Fiuchphointe: 653. 0 ± 55. 0 Céim

Dlús 1.51

Teocht stórála. {-20 Reoiteoir céime

intuaslagthacht DMSO (beagán), meatánól (beagán)

PKA3.95 ± 0. 10

 

Iarratas:

Is é Vx -809 (Lumacaftor) an dara comhdhúil iarrthóra ó bhéal chun cóireáil a dhéanamh ar fiobróis chisteach (CF). Is féidir le VX -809 feidhm an phróitéin rialtóra tras -chraicinn fiobróis chisteach (CFTR) a athbhunú, ar fabht é sa phróitéin chill -membrane as a dtagann dul chun cinn cf. Bíonn tionchar ag an easnamh VX -809 i bpróitéin CFTR ar iompar ian clóiríde agus ian eile idir cealla, as a dtiocfaidh carnadh mucus slaodach i scamhóga othar CF. Is féidir leis an mucus seo ionfhabhtuithe ainsealacha agus athlasadh a chur chun cinn, rud a fhágann go bhfuil damáiste scamhóg dochúlaithe

 

Comhchiallaigh:

Lumacaftor

936727-05-8

Vx -809

VX 809

Vrt -826809

{3- (6- ({1- (2, 2- difluOrObenzo [d] [1,3] déxol -5- yl) cyclopropAneCarbox {}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} {}}}

{3- (6- {[{1- (2, 2- difluoro-benzo [1,3] déxol -5- yl) -cycl opropanecarbonyl] -amino} {-3- meitil-pyridin -2- yl) -Benzoicacid

Vx -809 (lumacaftor)

3- [6- [[{1- (2, 2- difluoro -1, 3- benzodioxol {{7} y l) cyclopropanecarbonyl] amino] -3- methylpyridin -2- yl] Benszoic aigéadach

{3- (6- {[{1- (2, 2- difluoro -2 H {-1, 3- benzodioxol {{{8} y l) cyclopropane -1- carbonyl] amino} -3- methylpyridin -2- yl) Benszoic aigéadach

Aigéad Bensóch, 3- (6- (((1-} (2, 2- difluoro -1, 3- benzodioxol {{{{{{{{{{{{{{{{{{{{{{{{{ 7}} yl) cyclopropyl) carbonyl) aimín) -3- meitil -2- pyridinyl)-

3- (6- [[{1- (2, 2- difluoro-benzo [1,3] déxol -5- yl) -cy -cy Clopropanecarbonyl] -amino] -3- meitil-pyridin -2- yl) -Benzoic Aigéadach

{3- (6- {[{1- (2, 2- difluoro-benzo [1,3] déxol -5- yl)- cyclopropanecarbonyl] -amino} -3- meitil-pyridin -2- yl) -be

{3- (6- ({1- (2, 2- difluOrObenzo (d) (1,3) déxyl -5- yl) cyclopropAneCaRboxAmido) {}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} {

{3- {6- [{1- (2, 2- difluoro -2 H -1, {3- benzodioxo l {-5- yl) cyclopropaneamido] -3- methylpyridin -2- yl} Benszoic aigéadach

lumacaforum

{3- (6- (({1- (2, 2- difluoro -2 H -1, {3- benzodioxol {{8} y y l) cyclopropane -1- carbonyl) aimín) -3- methylpyridin -2- yl) Benszoic aigéadach

 

 

 

Clibeanna Te: 936727-05-8 lumacaftor (vx {-809), an tSín 936727-05-8 lumacaftor (vx -809) monaróirí, soláthróirí